Dear Skyline Users,

I have just released Skyline 2.6, with many exciting new features, improved workflows and better peak picking.

This release includes the following improvements:

• Full-Scan spectrum view for chromatograms extracted from full-scan data, with heat-map graph for IMS data
  • If you are using chromatogram extraction workflows (MS1 filtering, PRM, DIA), then you really want this
    
• New Skyline start page for faster access to common starting scenarios and tutorials
• Ion mobility drift time filtering for Agilent and Waters TOF instruments
• Optimization library support for storing optimized CE values
• Custom fragment ion support for defining non-peptide-backbone fragments (like iTRAQ, TMT, etc.)
• Support for isotope labeling experiments (like SILAC) without standards
• Support for Shimadzu triple-quadrupole instruments
• Improved chromatogram peak picking
• Import of tabular "assay library" format
• Support for protein details information (accession number, gene name and preferred name) queried from internet sites
• DIA isolation scheme viewer
• Option to exclude transitions within the DIA isolation window for the precursor
• First draft translations for Chinese and Japanese, with more translated than in 2.5

Skyline should ask you to update automatically after you restart twice. If not, please check the following page before requesting support:

Recovering From a Broken Installation

Thanks for using Skyline in your research.

Brendan MacLean
Skyline Project Lead